{"created":"2024-05-15T07:20:33.880992+00:00","id":2000261,"links":{},"metadata":{"_buckets":{"deposit":"85b45e35-fbd2-4236-a4b3-0cc5fa2fb883"},"_deposit":{"created_by":19,"id":"2000261","owner":"19","owners":[19],"pid":{"revision_id":0,"type":"depid","value":"2000261"},"status":"published"},"_oai":{"id":"oai:niu.repo.nii.ac.jp:02000261","sets":["3:4:1712658663478"]},"author_link":["5613","6191","6192","6193","5796","5413","5408"],"control_number":"2000261","item_10_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2024-03-31","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"134","bibliographicPageStart":"129","bibliographicVolumeNumber":"24","bibliographic_titles":[{"bibliographic_title":"長崎国際大学論叢","bibliographic_titleLang":"ja"},{"bibliographic_title":"Nagasaki international university review","bibliographic_titleLang":"en"}]}]},"item_10_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"食物抗原に対する特異的IgEが産生され、アレルギー発症の準備段階となる状態を「感作」という。本研究では、感作条件の違いによる免疫グロブリン濃度、サイトカイン発現量の変化を検討し、食物アレルギーモデルラット作製条件の検討を行った。４週齢雄性BNラットを対照群、食物アレルゲンとしてオボアルブミン（OVA）0.5 mgを週に１回腹腔内投与する群、OVA 1 mgを毎日経口投与する群、OVA 2 mgを２日に１回経口投与する群に分けた。各条件で35日間飼育した結果、血漿OVA特異的IgE濃度は腹腔内投与群でのみ有意に上昇し、OVAへの感作が認められた。また、腹腔内投与群において、脾臓IL-4/IL-2の上昇がみられ、Th1/Th2バランスがTh2にバランスが傾いている可能性が示唆された。その結果、過剰な体液性免疫が生じ、OVA特異的IgEが増加したと考えられる。また、アレルゲンの経口投与では、経口免疫寛容が誘導される可能性もあることから、腹腔内投与による感作が効率的であると考えられる。","subitem_description_type":"Abstract"},{"subitem_description":"Sensitization is a pre-allergy state in which there is an increase in the production for allergen specific IgE. In this study, we have evaluated changes in immunoglobulin concentration and cytokine expression by different sensitization methods, for producing food allergy rat models. 4-week-old male BN rats were divided into four groups. 1) control group, 2) administration intraperitoneally of 0.5 mg ovalbumin (OVA) once a week, 3) administeration orally of 1 mg OVA daily, 4) administration orally of 2 mg OVA every 2 days. After 35 days, plasma OVA-specific IgE levels were found to be increased significantly only in the intraperitoneal group, indicating sensitization to OVA. In addition, the expression level of IL-4/IL-2 in the spleen was elevated in the intraperitoneally administered group. This suggests that the Th1/Th2 balance may be tilted toward Th2. This may have resulted in excessive humoral immunity and increased OVA-specific IgE. On the other hand, oral administration of allergens may induce oral tolerance, our results suggest that sensitization by intraperitoneal administration may be more efficient.","subitem_description_type":"Abstract"}]},"item_10_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"長崎国際大学研究センター","subitem_publisher_language":"ja"}]},"item_10_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11766493","subitem_source_identifier_type":"NCID"}]},"item_10_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-4094","subitem_source_identifier_type":"ISSN"}]},"item_10_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_970fb48d4fbd8a85","subitem_version_type":"VoR"}]},"item_1695772498567":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_access","date":[{"dateType":"Available","dateValue":"2024-04-01"}],"displaytype":"detail","filename":"RN24-129.pdf","filesize":[{"value":"3.1 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Ryoji","creatorNameLang":"en"}],"familyNames":[{"familyName":"吉村","familyNameLang":"ja"},{"familyName":"ヨシムラ","familyNameLang":"ja-Kana"},{"familyName":"YOSHIMURA","familyNameLang":"en"}],"givenNames":[{"givenName":"亮二","givenNameLang":"ja"},{"givenName":"リョウジ","givenNameLang":"ja-Kana"},{"givenName":"Ryoji","givenNameLang":"en"}],"nameIdentifiers":[{"nameIdentifier":"5413","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"熊井, まどか","creatorNameLang":"ja"},{"creatorName":"ｸﾏｲ, ﾏﾄﾞｶ","creatorNameLang":"ja-Kana"}],"familyNames":[{"familyName":"熊井","familyNameLang":"ja"},{"familyName":"ｸﾏｲ","familyNameLang":"ja-Kana"}],"givenNames":[{"givenName":"まどか","givenNameLang":"ja"},{"givenName":"ﾏﾄﾞｶ","givenNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"5408","nameIdentifierScheme":"WEKO"}]}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"食物アレルギー","subitem_subject_scheme":"Other"},{"subitem_subject":"抗原感作","subitem_subject_scheme":"Other"},{"subitem_subject":"経口免疫寛容","subitem_subject_scheme":"Other"},{"subitem_subject":"Food allergy","subitem_subject_scheme":"Other"},{"subitem_subject":"Sensitization","subitem_subject_scheme":"Other"},{"subitem_subject":"Oral tolerance","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin 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