{"created":"2023-06-20T14:15:02.085846+00:00","id":767,"links":{},"metadata":{"_buckets":{"deposit":"012feae9-6f83-472d-b335-fc82c5efdeba"},"_deposit":{"created_by":3,"id":"767","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"767"},"status":"published"},"_oai":{"id":"oai:niu.repo.nii.ac.jp:00000767","sets":["3:4:19"]},"author_link":["1983","1985","1981","1982","1986","1984"],"item_10_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"240","bibliographicPageStart":"235","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"長崎国際大学論叢"},{"bibliographic_title":"Nagasaki International University Review","bibliographic_titleLang":"en"}]}]},"item_10_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"KODAMA, Tomoaki"}],"nameIdentifiers":[{"nameIdentifier":"1984","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"HARA, Sayuri"}],"nameIdentifiers":[{"nameIdentifier":"1985","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"YANO, Katsusuke"}],"nameIdentifiers":[{"nameIdentifier":"1986","nameIdentifierScheme":"WEKO"}]}]},"item_10_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10_description_24":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"Ghrelin is a 28-amino acid peptide with an acyl side chain, n-octanoic acid. It was reported that ghrelin infusion centrally and peripherally increases food intake. In this study, to investigate the effect of ghrelin to preference on nutrients, we infused ghrelin (0.5, 1.0 and 5.0 nmol/rat) intraperitoneally to rats, which were fed simultaneously three macronutrient diets (carbohydrate, protein and fat), and measured food intakes at 1, 2 and 4hr after infusion. Infusions of ghrelin increased dose-dependently total food intake compared with saline infusion. Infusion of ghrelin increased significantly carbohydrate intake, although protein and fat intakes did not altered. Serum glucose, total protein, albumin, triglyceride, free fatty acid and β-lipoprotein levels were did not altered with infusion of ghrelin. This study defined that ghrelin infusion increased selectively carbohydrate intake without metabolic changes. This result suggests that ghrelin may participate directly with the selective control of carbohydrate intake.","subitem_description_type":"Other"}]},"item_10_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"グレリンは２８個のアミノ酸から構成されるペプチドであり、その中枢あるいは末梢投与は、その後の摂食量を増加させることが報告されている。本研究ではグレリンの栄養素の嗜好性への影響を検討するため、３種類のマクロ栄養素食（糖質、タンパク質及び脂質）を同時に与えたラットにグレリン（０.５，１.０及び ５.０nmol/rat）を腹腔内投与し、投与から１、２、４及び２４時間後の摂食量を測定した。総摂食量はグレリンの投与量依存的に、生理的食塩水投与時と比べて増加した。その内訳を見ると、糖質食の摂食量が有意に増加していたが、タンパク質及び脂質食の摂食量に変化は見られなかった。血清グルコース、総タンパク質、中性脂肪、遊離脂肪酸、及びβ-リポタンパク質濃度はグレリン投与による影響は認められなかった。本研究はグレリンが代謝に影響することなく、糖質の摂食量を選択的に増加させたことを明らかにした。この結果は、グレリンが直接的に糖質に選択的な摂食調節に関与していることを示唆している。"}]},"item_10_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"長崎国際大学"}]},"item_10_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11766493"}]},"item_10_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-4094"}]},"item_10_subject_25":{"attribute_name":"Keyword","attribute_value_mlt":[{"subitem_subject":"Ghrelin, Food intake, Carbohydrate, Protein, Fat","subitem_subject_scheme":"Other"}]},"item_10_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"小玉, 智章"},{"creatorName":"ｺﾀﾞﾏ, ﾄﾓｱｷ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"原, 小由合"},{"creatorName":"ﾊﾗ, ｻﾕﾘ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"矢野, 捷介"},{"creatorName":"ﾔﾉ, ｶﾂｽｹ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-16"}],"displaytype":"detail","filename":"RN08-022.pdf","filesize":[{"value":"147.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"RN08-022","url":"https://niu.repo.nii.ac.jp/record/767/files/RN08-022.pdf"},"version_id":"c1a1dfb1-b7b9-49a8-a5e0-28c2a00fff66"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"グレリン"},{"subitem_subject":"摂食"},{"subitem_subject":"糖質"},{"subitem_subject":"タンパク質"},{"subitem_subject":"脂質"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"グレリンの腹腔内投与が栄養素選択的な摂食調節に及ぼす影響","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"グレリンの腹腔内投与が栄養素選択的な摂食調節に及ぼす影響"},{"subitem_title":"The Effect of Ghrelin Infusion Intraperitoneally to the Control of Food Intake with Nutrient Selection","subitem_title_language":"en"}]},"item_type_id":"10","owner":"3","path":["19"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-04-01"},"publish_date":"2015-04-01","publish_status":"0","recid":"767","relation_version_is_last":true,"title":["グレリンの腹腔内投与が栄養素選択的な摂食調節に及ぼす影響"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-21T06:17:54.040338+00:00"}