{"created":"2023-06-20T14:15:02.348791+00:00","id":771,"links":{},"metadata":{"_buckets":{"deposit":"d54afd16-1dbd-43af-9534-4b513b2ccafc"},"_deposit":{"created_by":3,"id":"771","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"771"},"status":"published"},"_oai":{"id":"oai:niu.repo.nii.ac.jp:00000771","sets":["3:4:19"]},"author_link":["1995","1996"],"item_10_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2008-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"281","bibliographicPageStart":"275","bibliographicVolumeNumber":"8","bibliographic_titles":[{"bibliographic_title":"長崎国際大学論叢"},{"bibliographic_title":"Nagasaki International University Review","bibliographic_titleLang":"en"}]}]},"item_10_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"HAMASAKI, Naotaka"}],"nameIdentifiers":[{"nameIdentifier":"1996","nameIdentifierScheme":"WEKO"}]}]},"item_10_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10_description_24":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"In this review, we summarize studies from Asian and Caucasian countries and highlight the importance of the APC anticoagulant system in coagulation regulation in vivo. Thrombophilia is defined as an increased tendency to thrombosis, and can be either inherited or acquired. It has been recognized that in Caucasians, a polymorphism of coagulation factor V, factor V Leiden (R506Q), is a major risk factor for venous thrombosis. However, this does not appear to be the case for Asian thrombophilia. Accumulated studies from Asian and Caucasian countries indicate that the frequencies of protein S deficiency and of protein C deficiency were higher in Asian patients suffering from deep vein thrombosis than in Caucasian patients, indicating that deficiency of the activated protein C (APC) anticoagulant system is more common in Asain than in Caucasian patients. This would suggest that these gene variants are responsible for the deficiency of the activated protein C anticoagulant system and that the deficiency of the activated protein C anticoagulant system is a major risk factor for venous thrombosis.","subitem_description_type":"Other"}]},"item_10_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"血栓性素因とは血栓症を発症しやすい体質のことである。欧米白人種の血栓性素因は、凝固系第五因子の１箇所の変異（Factor V Leiden（R５０６Q））であることが１０年余り前に判明し、欧米白人に対する血栓症対策は急速に進歩した。しかしながら、黒人やアジア人など欧米白人以外の人種では、Factor V Leiden（R５０６Q）を保因している人は皆無であり、これらの人種での血栓性素因の解明がいそがれていた。我々は日本人ならびにアジア人における血栓性素因の解明を目指して研究を行ってきた。その結果、日本人の血栓性素因は凝固制御系因子 Protein S 遺伝子変異であることが判明した。その後、最近になり、我々の結果を裏付ける結果がタイ、台湾、中国（香港）から次々に発表され Protein S 凝固制御系因子の異常が日本人のみならずアジア人の血栓性素因であることが証明されつつある。凝固制御系因子 Protein S は凝固系第五因子を制御することで過剰な血栓形成が起こらないように制御している因子であり、生体内では、凝固系第五因子と凝固制御系 Protein S のバランスが適切な血栓形成に重要な役割を果たしていることが推測される。今後は、凝固系第五因子と Protein S 凝固制御因子の関係を詳細に研究し、アジア人の血栓症発症予防ならびに治療対策を推進すべきと考えている。","subitem_description_type":"Abstract"}]},"item_10_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"長崎国際大学"}]},"item_10_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11766493","subitem_source_identifier_type":"NCID"}]},"item_10_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-4094","subitem_source_identifier_type":"ISSN"}]},"item_10_subject_25":{"attribute_name":"Keyword","attribute_value_mlt":[{"subitem_subject":"Deep vein thrombosis, protein S gene variant, factor V Leiden, Japanese thrombophilia, Protein S Tokushima","subitem_subject_scheme":"Other"}]},"item_10_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"濱崎, 直孝"},{"creatorName":"ﾊﾏｻｷ, ﾅｵﾀｶ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{"nameIdentifier":"1995","nameIdentifierScheme":"WEKO"}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-16"}],"displaytype":"detail","filename":"RN08-026.pdf","filesize":[{"value":"547.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"RN08-026","url":"https://niu.repo.nii.ac.jp/record/771/files/RN08-026.pdf"},"version_id":"f34157ea-0ac9-4b0c-9aed-88185994543e"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"深部静脈血栓症","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテインＳ分子異常","subitem_subject_scheme":"Other"},{"subitem_subject":"凝固第五因子ライデン変異体","subitem_subject_scheme":"Other"},{"subitem_subject":"日本人の血栓性素因","subitem_subject_scheme":"Other"},{"subitem_subject":"プロテインＳ徳島分子","subitem_subject_scheme":"Other"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper","resourceuri":"http://purl.org/coar/resource_type/c_6501"}]},"item_title":"アジア人特有な血栓性素因の研究","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"アジア人特有な血栓性素因の研究"},{"subitem_title":"Thrombophilia in Asia","subitem_title_language":"en"}]},"item_type_id":"10","owner":"3","path":["19"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-04-01"},"publish_date":"2015-04-01","publish_status":"0","recid":"771","relation_version_is_last":true,"title":["アジア人特有な血栓性素因の研究"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-21T06:18:02.603291+00:00"}