{"created":"2023-06-20T14:15:04.359252+00:00","id":805,"links":{},"metadata":{"_buckets":{"deposit":"8ffd198a-3e8d-4d4f-b20b-68bfdf3b7a64"},"_deposit":{"created_by":3,"id":"805","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"805"},"status":"published"},"_oai":{"id":"oai:niu.repo.nii.ac.jp:00000805","sets":["3:4:21"]},"author_link":["2134","2133","2131","2130","2132","2129"],"item_10_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2010-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"248","bibliographicPageStart":"239","bibliographicVolumeNumber":"10","bibliographic_titles":[{"bibliographic_title":"長崎国際大学論叢"},{"bibliographic_title":"Nagasaki International University Review","bibliographic_titleLang":"en"}]}]},"item_10_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"NODAKE, Yuichi"}],"nameIdentifiers":[{"nameIdentifier":"2132","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"FUKASAWA, Masashi"}],"nameIdentifiers":[{"nameIdentifier":"2133","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SAKAKIBARA, Ryuzo"}],"nameIdentifiers":[{"nameIdentifier":"2134","nameIdentifierScheme":"WEKO"}]}]},"item_10_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10_description_24":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"A novel supramolecular oligomer, cyclic polylactate (CPL), was originally discovered in the culture medium of tumor cells. CPL suppresses the growth of tumor cells by inhibiting the activities of enzymes involved in the glycolytic pathway, pyruvate kinase and lactate dehydrogenase. Application of CPL was found to induce apoptosis in tumor cells through 7A6 antigen expression and DNA ladder formation. In addition, CPL is reported to prolong significantly the survival period of tumor bearing mice. These findings suggest that CPL might be a useful chemotherapeutic agent for cancers.","subitem_description_type":"Other"}]},"item_10_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"乳酸を環状に重合した化合物である環状重合乳酸（CPL）が、ガン細胞の増殖を強力に抑制することが見出されている。CPLのこの特異な生理活性が脚光を浴び、CPLを新しいタイプの機能性食品や抗ガン剤として応用するための試みが精力的に実施されている。　CPLはガン細胞のピルビン酸キナーゼおよび乳酸脱水素酵素の活性阻害に効果を示し、ガン細胞の解糖系を特異的に抑制する特長を示す。この結果、解糖系の機能が低下したガン細胞においては、エネルギーおよび細胞構成成分の産生・供給が停滞状態に陥る。また、CPLの作用によりガン細胞ではアポトーシスも誘導されることから、ガンの成長が抑制されることが示されている。現在では、ガン患者を対象としたCPLの臨床試験も実施されており、腫瘍の縮小や症状の改善に関する症例報告がある。"}]},"item_10_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"長崎国際大学"}]},"item_10_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11766493"}]},"item_10_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-4094"}]},"item_10_subject_25":{"attribute_name":"Keyword","attribute_value_mlt":[{"subitem_subject":"Cyclic polylactate, anti-tumor effect, glycolysis, pyruvate kinase, lactate dehydrogenase","subitem_subject_scheme":"Other"}]},"item_10_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"野嶽, 勇一"},{"creatorName":"ﾉﾀﾞｹ, ﾕｳｲﾁ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"深澤, 昌史"},{"creatorName":"ﾌｶｻﾜ, ﾏｻｼ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"榊原, 隆三"},{"creatorName":"ｻｶｷﾊﾞﾗ, ﾘｭｳｿﾞｳ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-14"}],"displaytype":"detail","filename":"RN10-025.pdf","filesize":[{"value":"532.2 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"RN10-025","url":"https://niu.repo.nii.ac.jp/record/805/files/RN10-025.pdf"},"version_id":"1c2cc21a-3b34-4abc-ad5b-3d12464d878c"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"環状重合乳酸"},{"subitem_subject":"ガン細胞増殖抑制"},{"subitem_subject":"解糖系"},{"subitem_subject":"ピルビン酸キナーゼ"},{"subitem_subject":"乳酸脱水素酵素"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"jpn"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"環状重合乳酸のガン細胞増殖抑制効果","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"環状重合乳酸のガン細胞増殖抑制効果"},{"subitem_title":"The Anti-Tumor Effect of Cyclic Polylactate","subitem_title_language":"en"}]},"item_type_id":"10","owner":"3","path":["21"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-04-01"},"publish_date":"2015-04-01","publish_status":"0","recid":"805","relation_version_is_last":true,"title":["環状重合乳酸のガン細胞増殖抑制効果"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-21T06:16:58.378699+00:00"}