{"created":"2023-06-20T14:15:05.212237+00:00","id":818,"links":{},"metadata":{"_buckets":{"deposit":"fe09fc6d-ad06-4514-a110-97697b9cd795"},"_deposit":{"created_by":3,"id":"818","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"818"},"status":"published"},"_oai":{"id":"oai:niu.repo.nii.ac.jp:00000818","sets":["3:4:22"]},"author_link":["2165","2168","2167","2166"],"item_10_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2011-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"130","bibliographicPageStart":"119","bibliographicVolumeNumber":"11","bibliographic_titles":[{"bibliographic_title":"長崎国際大学論叢"},{"bibliographic_title":"Nagasaki International University Review","bibliographic_titleLang":"en"}]}]},"item_10_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"DU, Xiao-Ming"}],"nameIdentifiers":[{"nameIdentifier":"2167","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"SHOYAMA, Yukihiro"}],"nameIdentifiers":[{"nameIdentifier":"2168","nameIdentifierScheme":"WEKO"}]}]},"item_10_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10_description_24":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"In this review we discuss the pharmacological activities of Anoectochilus formosanus in mice and the clinical evidences using volunteers, and the determination of an active component from A. formosanus. The extract of A. formosanus showed significant activity in decreasing the levels of the cytosolic enzymes LDH, GOT and GPT, and the result demonstrated that in vitro cultured A. formosanus possessed prominent hepatoprotective activity against CCl4-induced hepatotoxicity. In the test using aurothioglucose-induced obese mice, the extract of A. formosanus showed a significant antihyperliposis effect. The body and liver weights were significantly suppressed ameliorating TG levels in the liver and serum in the extract treated group. When the high TG volunteers were used, the administration of A. formosanus significantly decreased the levels of TC, VLDL and Apo E. The results of the present study suggest that A. formosanus may be useful for improvement of lipid-metabolism and the prevention of atherosclerosis. A. formosanus grown in wild and propagated by tissue culture contain ten compounds including a major known component, kinsenoside and two new components, 3-(R)-3-β-D-glucopyranosyloxy-4-hydroxybutanoic acid, and 2-(β-D-glucopyranosyloxymethyl)-5-hydroxymethylfuran, along with the known compounds, 1-O-isopropyl-β-D-glucopyranoside, (R)-(+)-3,4-dihydroxy-butanoic acid γ-lactone, 4-(β-D-glucopyranosyloxy)benzyl alcohol, (6R,9S)-9-hydroxy-megastigma-4,7-dien-3-one-9-O-β-D-glucopyranoside, and corchoionoside C. In an anti-hyperliposis assay using high-fat diet rats and in aurothioglucose-induced obese mouse, kinsenoside significantly reduced the weights of body and liver, and also decreased the triglyceride level in the liver compared to those of control rats.","subitem_description_type":"Other"}]},"item_10_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"本総説において以下の知見を得たのでこれらについて述べる｡1)ﾏｳｽを用いた金線連の薬理活性､特に肝障害改善作用について検討した｡2)ﾎﾞﾗﾝﾃｲｱによる脂質関連障害の改善傾向を認めた｡3)金線連の粗ｴｷｽから脂質代謝改善作用を指標として kinsenoside を単離し､本化合物が活性本体であることを明らかにした｡ﾗﾝ科に属する金線連(Anoectochilus formosanus Hayata)は台湾から沖縄にかけて自生しており､高血圧､肺障害､肝障害､小児の発育障害等に用いられてきた｡原料の枯渇から金線連の近縁種が代用として用いられるようになってきた｡かかる現状から研究材料を確保する目的で､金線連の完熟種子を培地へ無菌的に播種し､発芽後幼植物を得た｡このものを液体培地で培養し､植物体を得て実験材料とした｡金線連のｴｷｽは四塩化炭素で誘導する肝細胞障害を抑制することが判明した｡また､ﾏｳｽの体重増加や肝重量増加を抑制した｡さらにﾏｳｽの肝臓や血清中の脂質を低下させる作用が認められた｡ﾎﾞﾗﾝﾃｲｱによる金線連ｴｷｽの臨床試験の結果､健常者には作用しないが､脂質やｺﾚｽﾃﾛｰﾙ､またその両者が高い患者に対しては VLDL や LDL､ALT､AST 値を下げることが明らかとなった｡培養金線連を抽出しｶﾗﾑｸﾛﾏﾄにて成分の精製単離を行い､8種の化合物を単離し構造を明らかにした｡その中で量的にも多い kinsenoside についてはX-線解析を行い､絶対構造を明らかにした｡金線連ｴｷｽにつき脂質代謝を指標として分画を行い､kinsenoside がその活性本体であることを明らかにした｡Kinsenoside を金線連ｴｷｽ同様の評価系にて評価した結果､肝臓や子宮の脂質量低下作用があることが明らかとなった｡脂肪肝を発症させたﾏｳｽに kinsenoside を与えて顕微鏡により調査した結果､0.2%の kinsenoside を与えることにより脂肪肝は改善されることが明らかとなった｡"}]},"item_10_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"長崎国際大学"}]},"item_10_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11766493"}]},"item_10_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-4094"}]},"item_10_subject_25":{"attribute_name":"Keyword","attribute_value_mlt":[{"subitem_subject":"Anoectochilus species, Orchidaceae, kinsenoside, antihyperliposis, hepatoprotective activity","subitem_subject_scheme":"Other"}]},"item_10_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"DU, Xiao-Ming"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"正山, 征洋"},{"creatorName":"ｼｮｳﾔﾏ, ﾕｷﾋﾛ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-14"}],"displaytype":"detail","filename":"RN11-013.pdf","filesize":[{"value":"626.9 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"RN11-013","url":"https://niu.repo.nii.ac.jp/record/818/files/RN11-013.pdf"},"version_id":"dabfa837-8189-43e1-91bd-095e7706f780"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"Anoectochilus 属植物"},{"subitem_subject":"ﾗﾝ科"},{"subitem_subject":"ｷﾝｾﾉｼﾄﾞ"},{"subitem_subject":"抗高脂血漿"},{"subitem_subject":"肝保護作用"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"金線連の活性成分","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"金線連の活性成分"},{"subitem_title":"Study on Bioactive Components of Anoectochilus formosanus Hayata","subitem_title_language":"en"}]},"item_type_id":"10","owner":"3","path":["22"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-04-01"},"publish_date":"2015-04-01","publish_status":"0","recid":"818","relation_version_is_last":true,"title":["金線連の活性成分"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-21T06:16:33.797404+00:00"}