{"created":"2023-06-20T14:15:09.706624+00:00","id":923,"links":{},"metadata":{"_buckets":{"deposit":"bcbbb945-fa05-40f7-8686-7404e9f13bed"},"_deposit":{"created_by":3,"id":"923","owners":[3],"pid":{"revision_id":0,"type":"depid","value":"923"},"status":"published"},"_oai":{"id":"oai:niu.repo.nii.ac.jp:00000923","sets":["3:4:35"]},"author_link":["2838","2836","2841","2842","2840","2835","2837","2839"],"item_10_biblio_info_7":{"attribute_name":"書誌情報","attribute_value_mlt":[{"bibliographicIssueDates":{"bibliographicIssueDate":"2015-03","bibliographicIssueDateType":"Issued"},"bibliographicPageEnd":"173","bibliographicPageStart":"167","bibliographicVolumeNumber":"15","bibliographic_titles":[{"bibliographic_title":"長崎国際大学論叢"},{"bibliographic_title":"Nagasaki International University Review","bibliographic_titleLang":"en"}]}]},"item_10_creator_3":{"attribute_name":"著者別名","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"TANAKA, Hiromitsu"}],"nameIdentifiers":[{"nameIdentifier":"2839","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"TSUJIMURA, Akira"}],"nameIdentifiers":[{"nameIdentifier":"2840","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"MIYAGAWA, Yasushi"}],"nameIdentifiers":[{"nameIdentifier":"2841","nameIdentifierScheme":"WEKO"}]},{"creatorNames":[{"creatorName":"WADA, Morimasa"}],"nameIdentifiers":[{"nameIdentifier":"2842","nameIdentifierScheme":"WEKO"}]}]},"item_10_description_19":{"attribute_name":"フォーマット","attribute_value_mlt":[{"subitem_description":"application/pdf","subitem_description_type":"Other"}]},"item_10_description_24":{"attribute_name":"Abstract","attribute_value_mlt":[{"subitem_description":"TEKTIN proteins contribute to the formation of cilia and flagella together with dynein. At least six types of TEKTIN genes have been reported in humans. The disruption of Tektin-t/Tekt2, Tekt3, or Tekt4 in mice causes sperm flagellar dysfunction, and Tektin-t/Tekt2 null male mice are infertile. To investigate the possible association between variations in TEKTIN-t/TEKT2 and impaired spermatogenesis in Japanese males, we screened for mutations in TEKTIN-t/TEKT2 using DNA from 282 sterile male patients and 89 proven-fertile male volunteers. Six polymorphisms were found in the open reading frame of TEKTIN-t/TEKT2, but no significant differences in genotype frequency were identified in the infertile subjects(P>0.05). We also did not detect a previously reported TEKTIN-t/TEKT2 gene variant in our subjects. These data may be applied to future large-scale genetic analyses of the association between genetic background and male infertility.","subitem_description_type":"Other"}]},"item_10_description_5":{"attribute_name":"抄録","attribute_value_mlt":[{"subitem_description":"ﾃｸﾁﾝは､ﾀﾞｲﾆﾝとともに精子の鞭毛や繊毛の形成に関与したﾀﾝﾊﾟｸ質である｡ﾃｸﾁﾝには､ﾋﾄにおいて少なくとも6種類の遺伝子の存在が報告されている｡ﾃｸﾁﾝ遺伝子のうち､Tektin-t/Tekt2､Tekt3､もしくは Tekt4 が欠失することによって､精子の鞭毛が機能不全を起こし､なかでも Tektin-t/Tekt2 遺伝子の欠失は､雄性不妊症になることがﾏｳｽで示されている｡男性不妊症の原因にﾃｸﾁﾝ遺伝子の機能不全が関与することが予想される｡私たちは､ﾋﾄ TETIN-t/TEKT2 遺伝子の遺伝子多型と男性不妊症との関係について調べるため､282人の原因不明の男性不妊症患者と89人の妊孕性が確認された男性ﾎﾞﾗﾝﾃｨｱの遺伝子の解析を行った｡その結果､日本人男性不妊症患者に有意に検出される TETIN-t/TEKT2 遺伝子の変化は見られなかった｡これらの結果は､TETIN-t/TEKT2 は､日本人男性不妊症の原因遺伝子となる割合は非常に低くいことを示すとともに､今後の大規模な男性不妊症の原因となる遺伝子の解析に役に立つものと考えられる｡"}]},"item_10_publisher_8":{"attribute_name":"出版者","attribute_value_mlt":[{"subitem_publisher":"長崎国際大学"}]},"item_10_source_id_11":{"attribute_name":"書誌レコードID","attribute_value_mlt":[{"subitem_source_identifier":"AA11766493"}]},"item_10_source_id_9":{"attribute_name":"ISSN","attribute_value_mlt":[{"subitem_source_identifier":"1346-4094"}]},"item_10_subject_25":{"attribute_name":"Keyword","attribute_value_mlt":[{"subitem_subject":"Infertility, genome, SNPs, spermatogenesis, testis","subitem_subject_scheme":"Other"}]},"item_10_version_type_20":{"attribute_name":"著者版フラグ","attribute_value_mlt":[{"subitem_version_resource":"http://purl.org/coar/version/c_ab4af688f83e57aa","subitem_version_type":"AM"}]},"item_creator":{"attribute_name":"著者","attribute_type":"creator","attribute_value_mlt":[{"creatorNames":[{"creatorName":"田中, 宏光"},{"creatorName":"ﾀﾅｶ, ﾋﾛﾐﾂ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"辻村, 晃"},{"creatorName":"ﾂｼﾞﾑﾗ, ｱｷﾗ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"宮川, 康"},{"creatorName":"ﾐﾔｶﾞﾜ, ﾔｽｼ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]},{"creatorNames":[{"creatorName":"和田, 守正"},{"creatorName":"ﾜﾀﾞ, ﾓﾘﾏｻ","creatorNameLang":"ja-Kana"}],"nameIdentifiers":[{}]}]},"item_files":{"attribute_name":"ファイル情報","attribute_type":"file","attribute_value_mlt":[{"accessrole":"open_date","date":[{"dateType":"Available","dateValue":"2022-05-14"}],"displaytype":"detail","filename":"RN15-015.pdf","filesize":[{"value":"314.3 kB"}],"format":"application/pdf","licensetype":"license_11","mimetype":"application/pdf","url":{"label":"RN15-015","url":"https://niu.repo.nii.ac.jp/record/923/files/RN15-015.pdf"},"version_id":"24663d09-4bfd-4fc9-a346-f5faa4fe0b9f"}]},"item_keyword":{"attribute_name":"キーワード","attribute_value_mlt":[{"subitem_subject":"不妊症"},{"subitem_subject":"ｹﾞﾉﾑ"},{"subitem_subject":"一塩基多型"},{"subitem_subject":"精子形成"},{"subitem_subject":"精巣"}]},"item_language":{"attribute_name":"言語","attribute_value_mlt":[{"subitem_language":"eng"}]},"item_resource_type":{"attribute_name":"資源タイプ","attribute_value_mlt":[{"resourcetype":"departmental bulletin paper"}]},"item_title":"鞭毛機能に必須なTEKTIN-t/TEKT2遺伝子の日本人男性における遺伝子多型の解析","item_titles":{"attribute_name":"タイトル","attribute_value_mlt":[{"subitem_title":"鞭毛機能に必須なTEKTIN-t/TEKT2遺伝子の日本人男性における遺伝子多型の解析"},{"subitem_title":"Discovery of a TEKTIN-t/TEKT2 Gene Variant Encoding Sperm Flagellar Protein in Japanese Males","subitem_title_language":"en"}]},"item_type_id":"10","owner":"3","path":["35"],"pubdate":{"attribute_name":"公開日","attribute_value":"2015-04-01"},"publish_date":"2015-04-01","publish_status":"0","recid":"923","relation_version_is_last":true,"title":["鞭毛機能に必須なTEKTIN-t/TEKT2遺伝子の日本人男性における遺伝子多型の解析"],"weko_creator_id":"3","weko_shared_id":3},"updated":"2023-07-21T06:14:25.913027+00:00"}